Cell surface expression screening

Many proteins that express to the surface of cells are targets for the discovery and development of biopharmaceuticals. For instance, G-protein coupled receptors (GPCRs) are the largest class of cell-surface proteins and are targets for almost 40% of existing drugs. Discovery and selection of high value clones with elevated cell surface expression of GPCRs from a transfected pool of cells can be challenging. The ClonePix 2 System represents an automated method of screening large populations of cells that increases the probability of finding rare high-affinity binder or high producer.

• Rapid automated selection of mammalian cell colonies by cell surface protein expression
• Rapid selection and development of GPCR expressing mammalian cell lines using novel ClonePix Technology
• Rapid and efficient selection of high producing mammalian cells secreting non-mAb proteins