Disease Modeling

Understanding the biology of human diseases is crucial to find effective treatment, and cell lines derived from cancer tissues help develop better anti-cancer drugs. However, now there is a pressing need to increase complexity and relevance of cell-based models to more accurately predict the effects of new drug candidates. Genetically engineered human or animal cells that carry disease mutation display all or some of the pathological processes observed in actual human disease. Designing 3D models that mimic tissues and cell interactions allows researchers to better predict drug effects. 3D cell models, including spheroids, organoids, and organ-on-a-chip, can be built from established cell lines derived from iPSC cells or patient derived cells. Cells can be derived from patient tissue representing rare type of cancer, or genetically modified to introduce or repair disease-related genes.

• Webinar: Establishing and imaging 3D oncology models
• Webinar: Disease modeling in the 21st century: Automated organoid assays with 3D imaging
• Publication: Disease Modeling with 3D Cell-Based Assays Using a Novel Flowchip System and High-Content Imaging
• Webinar: Capturing the complexity of 3D biology: Organoids for disease modelling and toxicity research
• Poster: Novel assay methods for cancer patient derived organoids
• Customer Breakthrough: Bioneer use the ImageXpress Micro Confocal for high-throughput imaging of 3D disease models
• Webinar: High-throughput, organoid-derived organ-on-a-chip systems for drug discovery and disease modelling