Dated: Aug 17, 2020
Publication Name: Springer
Citations : Drug Removal Strategies in Competitive Ligand Binding Neutralizing Antibody (NAb) Assays: Highly Drug-Tolerant Methods and Interpreting Immunogenicity Data
Neutralizing anti-drug antibody (NAb) assays often have lower drug tolerance (DT) than trough drug concentrations, potentially under-estimating NAb incidence. To improve DT, drug-specific proteins were coupled to magnetic beads to deplete drug in the sample.
Contributors: Michael A. Partridge, Elif Kabuloglu Karayusuf, Gary Shyu, Camille Georgaros, Albert Torri & Giane Sumner