Dated: Oct 10, 2022
Publication Name: Cancer Research Communications
Citations : Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis
Mitochondria are multifaceted organelles which are important for bioenergetics, biosynthesis, and signaling in metazoans. Mitochondrial functions are frequently altered in cancer to promote both the energy and the necessary metabolic intermediates for biosynthesis required for tumor growth. Cancer stem cells (CSC) contribute to chemotherapy resistance, relapse, and metastasis. Recent studies have shown that while non-stem, bulk cancer cells utilize glycolysis, breast CSCs are more dependent on oxidative phosphorylation (OxPhos) and therefore targeting mitochondria may inhibit CSC function.
Contributors: Yoshimi Endo Greer, Lidia Hernandez; Emily M.J. Fennell; Manjari Kundu; Donna Voeller; Raj Chari, Samuel F. Gilbert, Thomas S.K. Gilbert; Shashikala Ratnayake; Binwu Tang; Markus Hafner, Qingrong Chen; Daoud Meerzaman; Edwin Iwanowicz; Christina M. Annunziata, Lee M. Graves, Stanley Lipkowitz